Chemotherapy was potentiated by E7449 and single agent experienced considerable antitumor exercise in BRCA-deficient xenografts. Also, E7449 inhibited Wnt/?-catenin signaling in colon cancer mobile lines, very likely via TNKS inhibition. In line with this possibility, E7449 stabilized axin and TNKS proteins leading to ?-catenin de-stabilization and

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